Synthesis and properties of 6-(2,6-dichlorophenyl)-3- (3-methyl-1H-pyrazol-5-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazine-7-carboxylic acid and its salts

Carboxylic acids and their derivatives are an important component of many biological processes. For example, they can be used to create new medicines that useful in the fight against various diseases. Additionally, compounds containing a thiazole moiety may possess beneficial properties practical pharmacy. The incorporation this heterocyclic structure molecules positively impact several characteristics, such as anti-inflammatory, antiviral, antifungal activities. Consequently, exploring novel combine fragment with carboxyl group holds promise for advancement drugs diagnostic tools contribute significantly battle numerous aim work was number organic inorganic salts 6-(2,6-dichlorophenyl)-3-(3-methyl-1H-pyrazol-5-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylic acid study properties, well selective determination potential these compounds. Materials methods. synthetic part involved sequential synthesis original compound 4-amino-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-triazole-3-thiol using well-established method described previous articles. next stage reaction thiol 2,3-dichlorobenzaldehyde medium glacial acetic acid. resulting Schiff base subsequently reacted 2-chloroethanoic tetrahydrofuran presence equimolar amount sodium hydride. Salts corresponding were formed during both bases aqueous-alcohol medium. structures all synthesized determined 1H NMR spectroscopy elemental analysis. individuality each confirmed high-performance liquid chromatography-mass spectrometry. Results. optimal conditions formation analysis pharmacokinetic parameters physicochemical ADME (absorption, distribution, metabolism, excretion) allowed identification promising selection more further investigation. Conclusions. 12 confirmed. Physical-chemical carried out selected in-depth research.